Dr. Yoshimitsu ITOH


Lecturer

Department of Chemistry and Biotechnology, School of Engineering

The University of Tokyo


itoh@macro.t.u-tokyo.ac.jp

Dr. Yoshimitsu Itoh was born 1977 in Kanagawa, Japan. He received a Ph.D. degree for experimental and theoretical investigation of organo-fluorine compounds under the direction of Prof. Koichi Mikami at Tokyo Institute of Technology in 2006. Then, he started his first postdoctoral research focusing on organometallic catalysis with Prof. Eiichi Nakamura at the University of Tokyo. His second postdoctoral research was completed in Columbia University starting from 2007 with Prof. Colin Nuckolls working on self-assembled monolayers and organic field effect transistors. In 2008, he began his academic career at the University of Tokyo as an assistant professor in Prof. Takuzo Aida’s group. He was promoted to Lecturer in 2016.  He is now interested in modulation of chemical systems (reaction, assembly, property) using electric field for developing novel functional materials.


Education

BS. Faculty of Engineering, Tokyo Institute of Technology (2001)

MS. Graduate School of Engineering, Tokyo Institute of Technology (2003)

Ph.D Graduate School of Engineering, Tokyo Institute of Technology (2006)


Antecedents

2001.4–2006.3: Graduate Student, Tokyo Institute of Technology (with Prof. Koichi Mikami)

2005.7–2005.9: Visiting Graduate Student, University of California, Los Angels (with Prof. K. N. Houk)

2006.4–2007.8: JSPS Research Fellow, The University of Tokyo (with Prof. Eiichi Nakamura)

2007.9–2008.8: JSPS Research Fellow, Columbia University (with Prof. Colin Nuckolls)

2008.9–2016.9: Assistant Professor, The University of Tokyo (with Prof. Takuzo Aida)

2016.10–present: Lecturer, The University of Tokyo (with Prof. Takuzo Aida)



Awards

2013: Gordon Research Conference (Self-Assembly & Supramolecular Chemistry) Emerging Leaders Award.

2016: Chemical Society of Japan, Lecture Award for Young Chemist.

2017: The Young Scientists’ Prize in The Commendation for Science and Technology by the Minister of Education,

          Culture, Sports, Science and Technology


Publications

Energetics of Baird aromaticity supported by inversion of photoexcited chiral [4n]annulene derivatives

Michihisa Ueda, Kjell Jorner, Young Mo Sung, Tadashi Mori, Qi Xiao, Dongho Kim, Henrik Ottosson, Takuzo Aida, and Yoshimitsu Itoh

Nature Commun. 2017, 8, 346.


Jumping Crystals of Pyrene Tweezers: Crystal-to-Crystal Transition Involving π/π-to-CH/π Assembly Mode Switching

Yoshiki Shibuya, Yoshimitsu Itoh, and Takuzo Aida

Chem. Asian J. 2017, 12, 811-815.


Electrophoretic Deposition for Cholesteric Liquid-Crystalline Devices with Memory and Modulation of Reflection Colors.

Shoichi Tokunaga, Yoshimitsu Itoh, Yuya Yaguchi, Hiroyuki Tanaka, Fumito Araoka, Hideo Takezoe, Takuzo Aida

Adv. Mater. 2016, 28, 4077–4083.


Subnanoscale Hydrophobic Modulation of Salt Bridges in Aqueous Media

S. Chen, Y. Itoh, T. Masuda, S. Shimizu, J. Zhao, J. Ma, S. Nakamura, K. Okuro, H. Noguchi, K. Uosaki, T. Aida

Science 2015, 348, 555–559.


A Rational Strategy for the Realization of Chain-Growth Supramolecular Polymerization

J. Kang, D. Miyajima, T. Mori, Y. Inoue, Y. Itoh, T. Aida

Science 2015, 347, 646–651.


C5-Symmetric Chiral Corannulenes: Desymmetrization of Bowl Inversion Equilibrium via “Intramolecular” Hydrogen-Bonding Network

Jiheong Kang, Daigo Miyajima, Yoshimitsu Itoh, Tadashi Mori, Hiroki Tanaka, Masahito Yamauchi, Yoshihisa Inoue, Soichiro Harada, and Takuzo Aida

J. Am. Chem. Soc. 2014, 136, 10640–10644.


Homochiral supramolecular polymerization of bowl-shaped chiral macrocycles in solution

K. Sato, Y. Itoh, T. Aida

Chem. Sci. 2014, 5, 136–140.


Theoretical Study on the Regioselectivity of Baeyer–Villiger Reaction of α-Me-, -F-, -CF3-Cyclohexanones

  1. Y.Itoh, M. M. Yamanaka, K. Mikami

J. Org. Chem. 2013, 78, 146–153.


Columnarly Assembled Liquid Crystalline Peptidic Macrocycles Unidirectionally Orientable over a Large Area by Electric Field.

K. Sato, Y. Itoh, T. Aida
J. Am. Chem. Soc. 2011, 133, 13767–13769.


Simple Formation of C60 and C60-Ferrocene Conjugated Monolayers Anchored onto Silicon Oxide with Five Carboxylic Acids and Their Transistor Applications.

Y. Itoh, B. Kim, R. I. Gearba, N. J. Tremblay, R. Pindak, Y. Matsuo, E. Nakamura, C. Nuckolls

Chem. Mater. 2011, 23, 970–975.


Highly enantioselective synthesis of α-(perfluoroalkyl)amines via hydrogenation of enamide precursors in the presence of chiraphos-rhodium catalyst.

K. Mikami, T. Murase, L. Zhai, Y. Itoh, S. Ito

Tetrahedron Asymmetry 2010, 21, 1158–1161.


Activation of C-F Bonds in Preference to C-I Bonds: Difluoromethylation of Lithium Enolates with Trifluoromethyl Iodide

K. Mikami, Y. Tomita, Y. Itoh

Angew. Chem. Int. Ed. 2010, 49, 3819–3822.


Photovoltaic Universal Joints: Ball-and-Socket Interfaces in Molecular Photovoltaic Cells

N. J. Tremblay, A. A. Gorodetsky, M. P. Cox, T. Schiros, B. Kim, R. Steiner, Z. Bullard, A. Sattler, W.–Y. So, Y. Itoh, M. F. Toney, H. Ogasawara, A. P. Ramirez, I. Kymissis, M. L. Steigerwald, C. Nuckolls

ChemPhysChem 2010, 11, 799–803.


Sequential Perfluoroalkylation and Asymmetric Reduction of Nitriles Triggered with Perfluoroalkyl Titanates:

Catalytic Asymmetric Synthesis of Perfluoroalkyl Amines.

K. Mikami, T. Murase, L. Zhai, S. Kawauchi, Y. Itoh, S. Ito.

Tetrahedron Lett. 2010, 51, 1371–1373.


Efficient Formation of Ring Structures Utilizing Multisite Activation by Indium Catalysis

  1. Y.Itoh, H. Tsuji, K. Yamagata, K. Endo, I. Tanaka, M. Nakamura, E. Nakamura

J. Am. Chem. Soc. 2008, 130, 17161–17167.


Dialkylzinc-accelerated α-Trifluoromethylation of Carbonyl Compounds Catalyzed by Late-transition-metal Complexes

Y. Tomita, Y. Itoh, K. Mikami

Chem. Lett. 2008, 37, 1080–1081.


Modular Synthesis of Benzo[b]phosphole Derivatives via BuLi-Mediated Cyclization of (o-Alkynylphenyl)phosphin

H. Tsuji, K. Sato, L. Ilies, Y. Itoh, Y. Sato, E. Nakamura

Org. Lett. 2008, 10, 2263–2265.


Zncate-Type Enolate for Radical α-Trifluoromethylation

Y. Tomita, Y. Ichikawa, Y. Itoh, K. Kawada, K. Mikami

Tetrahedron Lett. 2007, 48, 8922–8925.


Indium-Catalyzed Cycloisomerization of ω-Alkynyl-β-ketoesters into Six- to Fifteen-Membered Rings

H. Tsuji, K. Yamagata, Y. Itoh, K. Endo, M. Nakamura, E. Nakamura

Angew. Chem. Int. Ed. 2007, 46, 8060–8062.


Tandem Reductive Perfluoroalkylation of Esters with Perfluoroalkyl Titanate-Type Reagents

K. Mikami, T. Murase, Y. Itoh

J. Am. Chem. Soc. 2007, 129, 11686–11687.


Catalytic Asymmetric Synthesis and Anticancer Effects of the Novel Non-Calcemic Analog of Vitamin D, 2α-Fluoro-19-nor-22-oxa-1α,25-dihydroxyvitamin D3 in Metastatic Lung Carcinoma

K. Nakagawa, T. Okano, K. Ozono, S. Kato, N. Kubodera, S. Ohba, Y. Itoh, K. Mikami

J. Fluorine Chem. 2007, 128, 654–667.


Trifluoromethylation of Metal Enolates and Theoretical Guideline

K. Mikami, Y. Itoh

In Current Fluoroorganic Chemistry. New Synthetic Directions, Technologies, Materials and Biological Applications;  V. A. Soloshonok, K. Mikami, T. Yamazaki, J. T. Welch, J. Honec, Eds.; American Chemical Society: Washington, DC, 2007; p 2–24.


Radical Trifluoromethylation of Ketone Silyl Enol Ethers by Activation with Dialkylzinc

K. Mikami, Y. Tomita, Y. Ichikawa, K. Amikura, Y. Itoh

Org. Lett. 2006, 8, 4671–4673.


Experimental and Theoretical Studies on Radical Trifluoromethylation of Titanium Ate and Lithium Enolates

Y. Itoh, K. N. Houk, K. Mikami

J. Org. Chem. 2006, 71, 8918–8925.


Radical Trifluoromethylation of Ketone Li Enolates

Y. Itoh, K. Mikami

Tetrahedron 2006, 62, 7199–7203.


Nanoflow Microreactor for Dramatic Increase not only in Reactivity but also in Selectivity: Baeyer-Villiger Oxidation by Aqueous Hydrogen Peroxide using Lowest Concentration of a Fluorous Lanthanide Catalyst

K. Mikami, M. Yamanaka, Md. N. Islam, T. Tonoi, Y. Itoh, M. Shinoda, K. Kudo

J. Fluorine Chem. 2006, 127, 592–596.


Radical Trifluoromethylation of Ti Ate Enolate: Possible Intervention of Transformation of Ti(IV) to Ti(III) for Radical Termination

Y. Itoh, K. Mikami

J. Fluorine Chem. 2006, 127, 539–544.


Metal Enolates of α-CF3 Ketones: Theoretical Guideline, Direct Generation, and Synthetic Use

K. Mikami, Y. Itoh

Chem. Rec. 2006, 6, 1–11.


Facile Radical Trifluoromethylation of Lithium Enolates

Y. Itoh, K. Mikami

Org. Lett. 2005, 7, 4883–4885.


Radical Trifluoromethylation of Titanium Ate Enolate

Y. Itoh, K. Mikami

Org. Lett. 2005, 7, 649–651.


Fluorinated Synthon: Asymmetric Catalytic Reactions

K. Mikami, Y. Itoh, M. Yamanaka

In Fluorine-Containing Synthons; V. A. Soloshonok Ed.; American Chemical Society: Washington, DC, 2005; p 356–367.


Direct Generation of Ti-Enolate of α-CF3 Ketone: Theoretical Study and High-Yielding and Diastereoselective Aldol Reaction

Y. Itoh, M. Yamanaka, K. Mikami

J. Am. Chem. Soc. 2004, 126, 13174–13175.


Hybrid Reagent of Ammonium Hydrogen Fluoride and Scandium Triflate: Highly Efficient Catalyst for Ring-Opening Fluorination of 2,3-Epoxyalcohols

Y. Itoh, S. Jang, S. Ohba, K. Mikami

Chem. Lett. 2004, 33, 776–777.


Nanoflow System for Perfect Regiocontrol in the Baeyer-Villiger Oxidation by Aqueous Hydrogen Peroxide using Lowest Concentration of a Fluorous Lanthanide Catalyst

K. Mikami, Md. N. Islam, M. Yamanaka, Y. Itoh, M. Shinoda, K. Kudo

Tetrahedron Lett. 2004, 45, 3681–3683.


Fluorinated Carbonyl and Olefinic Compounds: Basic Character and Asymmetric Catalytic Reactions

K. Mikami, Y. Itoh, M. Yamanaka

Chem. Rev. 2004, 104, 1–16.


Dipole Interaction-Controlled Stereoselectivity in Aldol Reaction of α-CF3 Enolate with Fluoral.

Y. Itoh, M. Yamanaka, K. Mikami

Org. Lett. 2003, 5, 4807–4809.


Complete Reversal in Regioselectivity in the Baeyer-Villiger Reaction of an α-CF3-Ketone and Theoretical Rationale for Axial Orientation of Sterically Demanding CF3 group at the Transition State

Y. Itoh, M. Yamanaka, K. Mikami

Org. Lett. 2003, 5, 4803–4806.


Organic Fluorine Compounds with Full of Character: Their (Catalytic) Asymmetric Synthesis (2).

K. Mikami, Y. Itoh, M. Yamanaka

Fine Chemical 2003, 32 (2), 11–20.


Organic Fluorine Compounds with Full of Character: Their (Catalytic) Asymmetric Synthesis (1).

K. Mikami, Y. Itoh, M. Yamanaka

Fine Chemical 2003, 32 (1), 35–50.